Yin-Yang! X-Change Alternative

Kaoru Sakurazuka is a normal Japanese young man, not unique in the least except for another person's features, which drive him crazy. His name doesn't thrill him either. He tries to never let people know that he has some of Sakuya Kamishiro's thoughts by trying to use all of his normal states of mind. He enjoys his time at school with his friends Touya and Renji.

In the game, Kaoru begins to have dizzy spells. After going to the school nurse—who's also famous for inventing new concoctions in the name of science—and accidentally using a vial of experimental medicine, Kaoru is shocked to wake up the next day to find that he's been transformed into a girl.