The Extracellular Matrix and the Tumor Microenvironment

The Extracellular Matrix and the Tumor Microenvironment



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English | 2022 | ISBN: 978-3-030-99708-3 | 493 pages | True PDF, EPUB | 44.7 MB

This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression.

Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression.