Science - 6 November 2015
English | 170 pages | PDF | 57.7 mb
NEWS
IN BRIEF
610 Roundup of the week’s news
IN DEPTH
613 HOW BURIED WATER MAKES DIAMONDS AND OIL
A new picture of water in the deep Earth predicts surprising chemistry By E. Hand
614 MICROBES AND CANCER DRUGS
Gut bacteria boost immunotherapies By M. Leslie
615 DATA CHECK: HOW A $30 BILLION HIKE BECOMES $3 BILLION
The new 2-year U.S. budget deal is frontloaded, with most of the spending increase coming in 2016 By J. Mervis
616 PACIFIC RIM MATHEMATICIANS COAXED FROM THEIR IVORY TOWERS
Programs to yoke math to industrial needs are booming in the Asia Pacific By D. Normile
617 INDIA ORDERS PREMIER LABS TO PAY THEIR OWN WAY
“Self-finance” directive comes as government pushes indigenous innovation By S. Ravindran
618 USING EVOLUTION TO BETTER IDENTIFY CELL TYPES
Gene expression patterns show that apparently related cells can have very different evolutionary histories By E. Pennisi
619 VITAMIN C COULD TARGET SOME COMMON CANCERS
Therapy kills tumor cells with difficultto- treat mutation By J. Kaiser
FEATURE
620 EGGS UNLIMITED
A company’s fertility treatments spark hope and disbelief By J. Couzin-Frankel
INSIGHTS
PERSPECTIVES
626 DENGUE VACCINES AT A CROSSROAD
Despite modest efficacy, a newly developed vaccine may be key for controlling dengue By A. Wilder-Smith and D. J. Gubler
628 A PANCREATIC CLOCK TIMES INSULIN RELEASE
Circadian oscillators of beta cells control insulin secretion and glucose homeostasis By C. Dibner and U. Schibler
629 LOVE AT SECOND SIGHT FOR CO2 AND H2 IN ORGANIC SYNTHESIS
Catalysts can combine H2 and CO2 to create building blocks for highvalue products By J. Klankermayer and W. Leitner
631 FRUSTRATING A QUANTUM MAGNET
Nuclear magnetic resonance reveals the ground state of frustrated magnets By Y. Furukawa
632 EVIDENCE GAPS AND ETHICAL REVIEW OF MULTICENTER STUDIES
Empirical research is needed to guide federal policy By A.-M. Ervin et al.
634 THE EPIGENOME—A FAMILY AFFAIR
Epigenome disruptions can be transmitted as altered histone modification patterns in sperm By J. R. McCarrey
635 HOW TO ISOLATE AMERICIUM
An electrolytic process enables isolation of the radioactive element americium from used nuclear fuel By C. Soderquist
636 A NEW DAWN FOR CATARACTS
Sterols reverse protein aggregation in an eye lens paradigm By R. A. Quinlan
BOOKS ET AL.
638 HOLDING FAST TO DREAMS By F. A. Hrabowski III, reviewed by I. M. Warner and G. Thomas
639 THE EVOLUTION OF EVERYTHING By M. Ridley, reviewed by R. Gawne
639 SPOOKY ACTION AT A DISTANCE By G. Musser
LETTERS
640 LIFT NIH RESTRICTIONS ON CHIMERA RESEARCH By A. Sharma et al.
640 MAKING SENSE OF THE TROUBLES AT NEON By S. V. Ollinger
641 ONLINE BUZZ: DISASTER PREPAREDNESS
DEPARTMENTS
609 EDITORIAL
Eradicating polio By Anthony Adams and David M. Salisbury
710 WORKING LIFE
Improving student advising By Rachel Bernstein
RESEARCH
IN BRIEF
646 From Science and other journals
REVIEW
649 MICROBIOME
Microbiomes in light of traits: A phylogenetic perspective J. B. H. Martiny et al.
RESEARCH ARTICLES
650 METABOLIC HEALTH
Pancreatic ß cell enhancers regulate rhythmic transcription of genes controlling insulin secretion M. Perelis et al.
651 EPIGENETICS
Disruption of histone methylation in developing sperm impairs offspring health transgenerationally K. Siklenka et al.
REPORTS
652 ACTINIDE CHEMISTRY
Electrochemical oxidation of 243Am(III) in nitric acid by a terpyridyl-derivatized electrode C. J. Dares et al.
655 FRUSTRATED MAGNETISM
Evidence for a gapped spin-liquid ground state in a kagome Heisenberg antiferromagnet M. Fu et al.
659 QUANTUM SIMULATION
Creation of a low-entropy quantum gas of polar molecules in an optical lattice S. A. Moses et al.
663 MICROBIOME
The ecology of the microbiome: Networks, competition, and stability K. Z. Coyte et al.
667 MOVEMENT CONTROL
Corticomotoneuronal cells are “functionally tuned” D. M. Griffin et al.
670 PLANT SCIENCE
Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory G. Shabuer et al.
674 OPHTHALMOLOGY
Pharmacological chaperone for a-crystallin partially restores transparency in cataract models L. N. Makley et al.
678 PROTEIN SYNTHESIS
Operon structure and cotranslational subunit association direct protein assembly in bacteria Y.-W. Shieh et al.
680 STRUCTURAL BIOLOGY
Crystal structure of the anion exchanger domain of human erythrocyte band 3 T. Arakawa et al.
684 PLANT EVOLUTION
The Papaver rhoeas S determinants confer self-incompatibility to Arabidopsis thaliana in planta Z. Lin et al.
688 PLANT GENETICS
A cucurbit androecy gene reveals how unisexual flowers develop and dioecy emerges A. Boualem et al.
691 NONHUMAN GENOMICS
The Symbiodinium kawagutii genome illuminates dinoflagellate gene expression and coral symbiosis S. Lin et al.